AUTHOR INFORMATION

Section 1 of 11

Authored by Corey M Long, MD, Department of Emergency Medicine, NYU Medical Center/Bellevue Hospital Center

Coauthored by Ugo Anthony Ezenkwele, MD, MPH, Assistant Professor, Assistant Professor of Emergency Medicine, Department of Emergency Medicine, New York University School of Medicine/Bellevue Hospital Center; Martin J Carey, MD, MPH, BCh, Program Director, Assistant Professor, Department of Emergency Medicine, University of Arkansas for Medical Sciences

Corey M Long, MD, is a member of the following medical societies: American College of Emergency Physicians

Edited by Francis Counselman, MD, Program Director, Chair, Professor, Department of Emergency Medicine, Eastern Virginia Medical School; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Eugene Hardin, MD, FACEP, FAAEM, Chair and Associate Professor, Department of Emergency Medicine, Charles R Drew University of Medicine and Science; Chair, Department of Emergency Medicine, Martin Luther King, Jr/Drew Medical Center; John Halamka, MD, Chief Information Officer, CareGroup Healthcare System, Assistant Professor of Medicine, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; Assistant Professor of Medicine, Harvard Medical School; and Steven C Dronen, MD, FAAEM, Director of Emergency Services, Director of Chest Pain Center, Department of Emergency Medicine, Ft Sanders Sevier Medical Center

Author's Email:	Corey M Long, MD
Editor's Email:	Francis Counselman, MD

eMedicine Journal, June 21 2006, VOLUME 7, Number 6

INTRODUCTION

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Background: In 1724, Dr Hermann Boerhaave described the first, and likely most well known, case of esophageal perforation. Baron von Wassenaer, the Grand Admiral of Holland, followed a large meal with his customary bout of emetic-induced vomiting. However, on this occasion, the Admiral experienced a sudden and severe pain in his upper abdomen after violent but minimally productive retching. Dead less than 24 hours later, his autopsy revealed a transverse tear of his distal esophagus and gastric contents in the pleural spaces. Spontaneous esophageal rupture is a rare and dangerous entity, which today is commonly known as Boerhaave Syndrome.

Today, most instances of esophageal perforation are iatrogenic, but this remains a potentially devastating condition. Rapid diagnosis and therapy provide the best chance for survival; however, delay in diagnosis is common, resulting in substantial morbidity and mortality. This article discusses the causes, investigation, and initial therapy for this potentially lethal gastrointestinal condition.

Pathophysiology: The esophagus is more vulnerable than the rest of the alimentary tract due to the lack of a serosal layer, which provides stability through elastin and collagen fibers. Perforation may be due to several mechanisms, including direct piercing, shearing along the longitudinal axis, bursting from radial forces, and thinning from necrosis of the esophageal wall.

Iatrogenic injury through esophageal instrumentation is the leading cause of perforation by either piercing or shearing and may be due to any number of procedures, especially endoscopy and dilatation of strictures. Such tears often occur near the pharyngoesophageal junction where the wall is weakest. Because the esophagus is surrounded by loose stromal connective tissue, the infectious and inflammatory response can disseminate easily to nearby vital organs, thereby making the esophageal perforation a medical emergency and increasing the likelihood of serious sequelae. Underlying esophageal disease (tumor, stricture) predisposes toward perforation with instrumentation, which often occurs distal to the affected area. Perforation during surgery most often occurs in the abdominal esophagus.

Spontaneous esophageal rupture (Boerhaave syndrome) occurs secondary to a sudden increase in intraluminal pressures, usually due to violent vomiting or retching, and often follows heavy food and alcohol intake. In more than 90% of cases, perforation occurs in the lower third of the esophagus; most frequently, the tear is in the left posterolateral region (90%) and may extend superiorly. The predilection for left-side perforation is due to the lack of adjacent supporting structures, thinning of the musculature in the lower esophagus, and anterior angulation of the esophagus at the left diaphragmatic crus. Fifty percent of ruptures occur in patients with gastroesophageal reflux disease, suggesting that ease of pressure transfer from the abdominal to thoracic esophagus may facilitate rupture.

Shearing forces due to rapid increases in intragastric pressure against a closed pylorus result in a Mallory-Weiss tear (MWT). These longitudinal mucosal lacerations occur most commonly at the gastroesophageal junction or gastric cardia, especially if a hiatal hernia is present, and often present with hematemesis. Ultimately, these tears can perforate if the pressure increases are unrelieved. Further discussion of MWTs is reserved for another section.

The cervical esophagus is the most common site of perforation by several other mechanisms as well, particularly in the region of the pyriform sinus. Trauma, almost uniformly penetrating, shows an affinity for the upper esophagus, while toxic ingestions and foreign bodies can directly damage the cervical esophagus or become lodged and cause insidious erosion of the muscle wall.

Frequency:

• In the US: Boerhaave syndrome is rare, accounting for 15% of all cases of esophageal perforation.

  Iatrogenic causes account for 50-75% of esophageal perforations. The actual incidence depends on the procedure; rigid endoscopy carries a perforation rate 0.1-0.4%, while that of flexible endoscopy varies from 0.01-0.06%. Rates increase quickly when interventions are undertaken, such as pneumatic balloon dilatation in achalasia (3-6%) or any procedure involving strictures secondary to radiation or tumor (10%). Furthermore, the rate of perforation is increased in the presence of a large hiatal hernia or esophageal diverticula.

  Penetrating trauma to the neck (2-9%), thinning of esophageal membrane secondary to variceal sclerotherapy (1-3%), and foreign body or toxic ingestions (5-15%) make up the bulk of the remaining causes.

Mortality/Morbidity: Even with prompt therapy and advances in surgical technique, the mortality rate can be very high, varying from 5-75%; higher rates correlate with delays in both presentation and diagnosis.

• Mortality also varies by etiology and location of the perforation. The highest rates are attributed to Boerhaave syndrome (up to 72%), partly because of the difficulty in making the diagnosis, followed by iatrogenic (19%) and traumatic perforations (7%). Cervical perforations portend a lower mortality compared with abdominal and thoracic perforations due to containment of potential contamination by tight fascial attachments and mechanisms, which may make injury more obvious.

• The morbidity and mortality in esophageal perforation is most often due to an overwhelming inflammatory response to gastric contents in the mediastinum, pleural spaces, and adjoining tissues, as well as swift spread of infection to paraesophageal structures. Negative intrathoracic pressure may draw gastric material out of the esophagus, exacerbating injury.

• Morbidity may be due to pneumonia, mediastinitis, empyema, polymicrobial sepsis, and multiorgan failure.

Race: No information on racial predilection is available.

Sex: Boerhaave syndrome is generally associated with vomiting and customarily occurs after drinking and eating binges. It is more commonly observed in males than in females. Iatrogenic perforation shows no predilection.

Age:

• Boerhaave syndrome is most common among patients aged 40-60 years old, but isolated case reports in children have been described.

• Iatrogenic perforations are associated with preexisting pathology and so are more common in fifth and later decades of life.

CLINICAL

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History:

• The classic presentation of spontaneous esophageal rupture is severe vomiting or retching followed by acute, severe chest or epigastric pain.

• Boerhaave syndrome has also been reported with abdominal or chest pain following straining, childbirth, weight lifting, fits of coughing or laughing, hiccuping, blunt trauma, seizures, and forceful swallowing.

• The presence of fever; pain in the neck, upper back, chest, or abdomen; dysphagia; odynophagia; dysphonia; or dyspnea following esophageal instrumentation should raise suspicion for perforation.

• Patients with thoracic or abdominal perforations may present with any of the above symptoms, as well as low back pain, shoulder pain referred from diaphragmatic irritation, increased discomfort lying flat, or true acute abdomen.

• The ingestion of a caustic toxin or foreign body preceding any of the above symptoms may indicate perforation.

• A history of preexisting upper gastrointestinal pathology (gastroesophageal reflux disease, hiatal hernia, carcinoma, strictures, radiation therapy, Barrett esophagus, varicies, achalasia, infection) raises a patient’s risk of perforation.

• Hematemesis, while occasionally present, is normally not a predominant symptom.

Physical:

• Although the physical examination is often nonspecific, certain findings can be helpful.

• Subcutaneous emphysema is palpable in the neck or chest in up to 60% of perforations but requires at least an hour to develop after the initial injury.

• Tachycardia and tachypnea are common initial physical examination findings, but fever may not be present for hours to days.

• The Mackler triad, consisting of vomiting, chest pain, and subcutaneous emphysema, is classically associated with spontaneous esophageal rupture, though it is only fully present in about 50% of cases.

• Auscultation of the chest can be of particular value.

• The Hamman sign is a raspy, crunching sound heard over the precordium with each heartbeat caused by mediastinal emphysema, often present with thoracic or abdominal perforations.

• Breath sounds may be reduced on the side of the perforation due to a contamination of the pleural space, often on the left.

• In cases of delayed presentation, patients may be critically ill and present with significant hypotension.

Causes:

• Iatrogenic etiologies predominate the causes of esophageal perforation, accounting for up to 85% of cases.

• Instrumentation modalities commonly include endoscopy, sclerotherapy, variceal ligation, pneumatic dilation, bougienage, and laser treatment.

• Placement of endotracheal, nasogastric, and Blakemore tubes represent less common iatrogenic causes.

• As detailed above, Boerhaave syndrome consistently accounts for about 15% of all perforations, normally secondary to vomiting after heavy food and alcohol intake, but possible by any action that abruptly increases intra-abdominal pressure against a closed superior esophageal sphincter.

• Swallowed foreign bodies may directly injure the esophagus by penetrating the tissue or becoming lodged at a point of esophageal narrowing, leading to pressure necrosis and wall weakness; pills and coins are common culprits. Ingestion of caustic chemicals may lead to direct wall inflammation and damage.

• Trauma represents an important cause of perforation, estimated at up to 10% of cases. Penetrating trauma is much far more prevalent than blunt, often in the form of knife or gun wounds, and is associated with significant injury to important adjacent cervical structures.

• Intraoperative esophageal perforation is a recognized complication of surgery, especially cardiothoracic or fundoplication, accounting for around 2% of all perforations.

DIFFERENTIALS

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Acute Coronary Syndrome
Aneurysm, Abdominal
Dissection, Aortic
Gastritis and Peptic Ulcer Disease
Myocardial Infarction
Pancreatitis
Pericarditis and Cardiac Tamponade
Pneumonia, Aspiration
Pneumonia, Bacterial
Pneumonia, Empyema and Abscess
Pneumothorax, Iatrogenic, Spontaneous and Pneumomediastinum
Pulmonary Embolism

Other Problems to be Considered:

Mallory-Weiss tear

WORKUP

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Lab Studies:

• Laboratory studies are of little value in confirming the diagnosis.

• If a diagnostic thoracentesis is performed on a pleural effusion, the presence of food particles, pH <6, or an elevated pleural fluid amylase are compatible with esophageal perforation.

Imaging Studies:

• Chest radiographs can be very helpful in diagnosing esophageal perforation, with suggestive abnormalities reported in about 90% of cases.

• Pneumomediastinum and subcutaneous emphysema are often present an hour after the injury and are highly suggestive of perforation.

• Mediastinal air-fluid levels, pleural effusions (often left sided), free air under diaphragm, pneumothorax, and hydropneumothorax encompass later potential findings.

• Lateral neck radiographs may demonstrate air in the fascial planes early in cases of cervical perforations.

• A contrast esophagogram should be performed in any patient with suspected perforation.

• Despite a modest sensitivity (60-75%), a water-soluble contrast agent (Gastrografin) should be the initial study of choice.

• A barium study should be undertaken immediately afterward should the initial study show no evidence of perforation.

• Barium has a higher sensitivity (90%) for detecting small perforations but may cause a severe inflammatory response in tissues, most notably a mediastinitis.

• Studies should be performed with the patient in the right lateral decubitus position.

• A contrast-enhanced CT scan of the chest should be obtained if it is not possible to obtain a contrast esophagogram, if the esophagogram was negative despite a high clinical suspicion, or if seeking to evaluate for a more likely alternative diagnosis. Perforation may be suggested by mediastinal air, extravasated luminal contrast, periesophageal fluid collections, pleural effusions, or actual communication of an air-filed esophagus with an adjacent mediastinal air-fluid collection; definitive esophageal communication with outside structures is often difficult to visualize.

Other Tests:

• Esophagoscopy often can be used to visualize perforations and is especially useful in acute traumatic perforations, but it is not appropriate when small mucosal tears are suspected, as insufflated air can cause further dissection of the perforation.

TREATMENT

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Prehospital Care: Any patient with an esophageal tear should be expeditiously transported to the emergency department with intravenous access, supplemental oxygen with a secure airway, and pain medication as necessary.

Emergency Department Care:

• Consideration of esophageal perforation as a diagnosis is the first and most important step in management. Emergency department treatment of any patient with suspected esophageal perforation depends on the severity of the injury and the patient’s hemodynamic stability, but will always include large-bore intravenous access, supplemental oxygen as necessary, and cardiopulmonary monitoring before further treatment is considered.

• Administration of broad-spectrum intravenous antibiotics should be instituted early in the evaluation.

• Patient should be made NPO and have a nasogastric tube placed to clear gastric contents and limit further contamination.

• Patient pain and discomfort may be significant; narcotic analgesia should be given as needed, judiciously in hypotensive patients.

• Patients with tenuous hemodynamic stability or any degree of airway compromise, especially those with Boerhaave syndrome, should undergo treatment in a setting with complete resuscitative facilities, including emergency airway equipment, as clinical decompensation can be precipitous.

• Rarely, tube thoracostomy may be urgently used to decompress the chest. Fluid removed is often gastric contents, occasionally pus, which is often present after significant delay in diagnosis.

• While historically treated exclusively with surgery, emerging evidence indicates that patients with small well-defined tears and minimal extraesophageal involvement may be better served by conservative treatment as outlined above.

• Originally put fourth by Cameron et al in 1979 and modified by Altorjay in 1997, the following represent suggested criteria for nonoperative management: Early diagnosis or delayed diagnosis with contained leak; tear outside abdomen, contained to mediastinum, draining to esophagus; draining to esophageal lumen by esophagography; tear does not involve neoplasm or obstruction; no signs or symptoms of sepsis; experienced thoracic surgeon and contrast imaging available.

• Specific surgical technique (primary repair, stent, resection, or drain placement) depends on the extent and location of injury, and is beyond the scope of this discussion.

Consultations: Obtain an emergent surgical consultation, cardiothoracic if available, as even patients initially managed nonoperatively could require surgery.

MEDICATION

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Analgesia and antibiotics are required for management.

Drug Category: Analgesics -- Pain control is essential to quality patient care. Ensures patient comfort, promotes pulmonary toilet, and enables physical therapy regimens. Many analgesics have sedating properties that are beneficial to patients who have sustained trauma.

Drug Name	Morphine sulfate (Duramorph, Astramorph, MS Contin) -- DOC for narcotic analgesia because of reliable and predictable effects, safety profile, and ease of reversibility with naloxone. IV doses may be administered in a number of ways, commonly titrated until desired effect is obtained.
Adult Dose	Sedation/analgesia before procedures: 3-4 mg IV q5min prn Initial dose: 0.1 mg/kg IV/IM/SC Analgesia: 2.5-20 mg IV/IM/SC q2-6h prn Continuous infusion: 0.8-10 mg IV q1h
Pediatric Dose	Emergency: 0.1-0.2 mg/kg IV Analgesia: 0.1-0.2 mg/kg IV/IM/SC q2-6h prn Continuous infusion: 0.01-0.04 mg/kg IV q1h Maximum dose: 15 mg
Contraindications	Documented hypersensitivity; hypotension; potentially compromised airway where establishing rapid airway control is difficult
Interactions	Phenothiazines may antagonize analgesic effects of opiate agonists; tricyclic antidepressants, MAOIs, and other CNS depressants may potentiate adverse effects
Pregnancy	B - Usually safe but benefits must outweigh the risks.
Precautions	Avoid in hypotension, respiratory depression, nausea, emesis, constipation, and urinary retention; caution in atrial flutter and other supraventricular tachycardias; has vagolytic action and may increase ventricular response rate

Drug Category: Antiemetics -- Useful in treating symptomatic nausea and preventing further contamination of pleural space.

Drug Name	Prochlorperazine (Compazine) -- An antidopaminergic drug that blocks postsynaptic mesolimbic dopamine receptors. Has an anticholinergic effect and can depress the reticular activating system. May be responsible for relieving nausea and vomiting.
Adult Dose	5-10 mg IV q2min
Pediatric Dose	<10 kg: Do not administer >10 kg: 0.1-0.2 mg/kg IV
Contraindications	Documented hypersensitivity; bone marrow suppression, narrow-angle glaucoma, and severe liver or cardiac disease
Interactions	Coadministration with other CNS depressants or anticonvulsants may cause additive effects; coadministration with epinephrine may cause hypotension
Pregnancy	B - Usually safe but benefits must outweigh the risks.
Precautions	Drug-induced Parkinson syndrome or pseudoparkinsonism occurs quite frequently; akathisia is most common extrapyramidal reaction in elderly persons; lowers seizure threshold; caution with history of seizures

Drug Name	Metoclopramide (Reglan) -- Dopamine antagonist that stimulates acetylcholine release in the myenteric plexus. Acts centrally on chemoreceptor triggers in the floor of the fourth ventricle, which provides important antiemetic activity.
Adult Dose	5-10 mg PO or 5-20 mg IV/IM tid prn
Pediatric Dose	1-2 mg/kg IV/IM 30 min before chemotherapy and q2-4h
Contraindications	Documented hypersensitivity; pheochromocytoma or GI hemorrhage, obstruction or perforation; history of seizure disorders
Interactions	Anticholinergic agents may antagonize effects of metoclopramide; opiate analgesics may increase metoclopramide toxicity in CNS
Pregnancy	B - Usually safe but benefits must outweigh the risks.
Precautions	Caution in history of mental illness and Parkinson disease

Drug Name	Promethazine (Phenergan) -- For symptomatic treatment of nausea in vestibular dysfunction. Antidopaminergic agent effective in treating emesis. Blocks postsynaptic mesolimbic dopaminergic receptors in brain and reduces stimuli to brainstem reticular system.
Adult Dose	12.5-25 mg PO/IV/IM/PR q4h prn
Pediatric Dose	<2 years: Contraindicated >2 years: 0.25-1.0 mg/kg PO/IV/IM/PR 4-6 times/d prn
Contraindications	Documented hypersensitivity; children younger than 2 y (incidences of death due to respiratory depression)
Interactions	May have additive effects when used concurrently with other CNS depressants or anticonvulsants; coadministration with epinephrine may cause hypotension
Pregnancy	C - Safety for use during pregnancy has not been established.
Precautions	Caution in cardiovascular disease, impaired liver function, seizures, sleep apnea, and asthma

Drug Category: Antibiotics -- Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Drug Name	Imipenem and cilastatin (Primaxin) -- Used for treatment of multiple organism infections in which other agents do not have wide spectrum coverage or are contraindicated because of their potential for toxicity.
Adult Dose	500-1000 mg IV q6h Patients with impaired renal function need lower doses
Pediatric Dose	Infants > 3 months and children <12 years: 50 mg/kg/d IV divided tid/qid
Contraindications	Documented hypersensitivity; known hypersensitivity to amide local anesthetics; children with CNS infections (increased seizure risk); children <30 kg with renal impairment (lack of data)
Interactions	Coadministration with cyclosporine may increase CNS side effects of both agents; coadministration with ganciclovir may result in generalized seizures
Pregnancy	C - Safety for use during pregnancy has not been established.
Precautions	Adjust dose in renal insufficiency (adult adjustments) CrCl (mL/min) 80-50: 0.5 g q6-8h CrCl 50-10: 0.5 g q8-12h Hemodialysis (HD): 0.25-0.5 g after HD, then q12h Adjust dose in renal insufficiency; avoid use in children <12 y with CNS infections Caution with history of seizures, hypersensitivity to penicillins, cephalosporins, or other beta lactam antibiotics

Drug Name	Piperacillin and tazobactam sodium (Zosyn) -- Semisynthetic extended-spectrum penicillin that inhibits bacterial cell wall synthesis by binding to specific PBPs; most effective of the antipseudomonal penicillins. Tazobactam increases piperacillin activity against S aureus, Klebsiella, Enterobacter, and Serratia species; (greatest increase in activity against B fragilis) but does not increase anti-P aeruginosa activity. Intra-abdominal and pelvic infections: The main pathogens in the lower abdomen and pelvis are aerobic coliform gram-bacilli and B fragilis. Enterococci are permissive and opportunistic pathogens and do not require special coverage.
Adult Dose	4.5 g IV q8h (piperacillin 4 g/tazobactam 0.5 g)
Pediatric Dose	<10 years: Not established >10 years: Administer as in adults
Contraindications	Documented hypersensitivity; severe pneumonia, bacteremia, pericarditis, emphysema, meningitis and purulent or septic arthritis should not be treated with an oral penicillin during the acute stage
Interactions	Tetracyclines may decrease effects of piperacillin; high concentrations of piperacillin may physically inactivate aminoglycosides if administered in same IV line; effects when administered concurrently with aminoglycosides are synergistic; probenecid may increase penicillin levels; high-dose parenteral penicillins may result in increased risk of bleeding
Pregnancy	B - Usually safe but benefits must outweigh the risks.
Precautions	Perform CBCs prior to initiation of therapy and at least weekly during therapy; monitor for liver function abnormalities by measuring AST and ALT during therapy; exercise caution in patients with hepatic insufficiencies; perform urinalysis, and BUN and creatinine determinations during therapy and adjust dose if values become elevated; monitor blood levels to avoid possible neurotoxic reactions

FOLLOW-UP

Section 8 of 11

Further Inpatient Care:

• Patients almost uniformly require intensive care unit admission because they may become septic and can have a complicated hospital course.

• Patients managed conservatively should take nothing by mouth and be administered parenteral antibiotics for 7-10 days; consideration should be given to intravenous nutrition in the event of a prolonged course. Repeat esophageal studies are utilized to ascertain treatment success.

Transfer:

• Patients with Boerhaave syndrome must be treated in a center with access to intensive care and cardiothoracic surgery. Transfer may be required to a tertiary care facility if these services are not available at the presenting hospital.

Complications:

• Complications include pneumonia, mediastinitis, sepsis, empyema, and adult respiratory distress syndrome.

• Because of improved management, a significant number of patients now survive; recurrent spontaneous ruptures of the esophagus have been described.

• Esophageal injuries secondary to penetrating trauma often involve adjacent structures such as the spinal cord and trachea.

Prognosis:

• The prognosis can be poor, especially if diagnosis is delayed. Even with prompt diagnosis and definitive therapy, the hospital course may be prolonged with high rates of morbidity and mortality.

• The prognosis of cervical iatrogenic perforation is far better than that of spontaneous perforation.

MISCELLANEOUS

Section 9 of 11

Medical/Legal Pitfalls:

• With a high index of suspicion, a negative water-soluble contrast study is not sufficient to rule out the diagnosis of esophageal tear.

• While evidence has begun to accumulate regarding specific treatment approaches, this remains a rare condition and, as such, many suggestions are based on case series or personal experience.

Special Concerns:

• Early diagnosis is crucial in Boerhaave syndrome. It is important to consider the possibility in any patient presenting with atypical chest or abdominal pain.

TEST QUESTIONS

Section 10 of 11

CME Question 1: Which of the following is the most common cause of esophageal tears?

A: Spontaneous rupture after vomiting (Boerhaave syndrome)
B: Penetrating trauma
C: Upper gastrointestinal endoscopy
D: Nasogastric tube placement
E: Foreign body aspiration

The correct answer is C: While all of the above are known etiologies of esophageal tears, iatrogenic injury remains by far the most common, accounting for up to 85% of all cases.

CME Question 2: Where does the esophagus generally rupture in spontaneous esophageal rupture?

A: On right side, proximally
B: On left side, proximally
C: On right side, distally
D: On left side, distally
E: Anywhere, transversely

The correct answer is D: The esophagus ruptures on the left side, distally in more than 90% of cases, and is normally longitudinal. This is due to a combination of the lack of adjacent supporting structures, thinning of the musculature in the lower esophagus, and anterior angulation of the esophagus at the left diaphragmatic crus. Rupture from iatrogenic injuries are more likely to involve the proximal esophagus and do not have a side predilection.

Pearl Question 1 (T/F): Spontaneous esophageal perforation usually is observed in patients aged 40-60 years.

The correct answer is True: A typical case involves a man aged 40-60 years who presents with severe chest pain following a drinking and/or eating binge after an episode of vomiting.

Pearl Question 2 (T/F): All patients with an esophageal perforation require surgery.

The correct answer is False: Although all patients with Boerhaave syndrome probably require a surgical drainage and repair procedure, conservative management may be appropriate in selected cases of iatrogenic perforation.

Pearl Question 3 (T/F): Negative results of water-soluble contrast studies may rule out the diagnosis of esophageal perforation.

The correct answer is False: In patients with a high suspicion for perforation and negative results of water-contrast studies, up to 25% can have perforation on barium contrast study.

Pearl Question 4 (T/F): Alcohol ingestion is a common precipitant to a proximal esophageal tear.

The correct answer is False: Proximal tears are most often iatrogenic, trauma-related, or from ingestions. Alcohol ingestion is associated with spontaneous esophageal tears, which normally involve the distal esophagus.

BIBLIOGRAPHY

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